Preclinical Research

 

Potential innovative phytomedicines coming out of the Natural Compound Research are tested by our in-house pharmacologists with regard to their efficacy and adverse event profile.

Extracts and single compounds are subjected to intensive pharmacological investigations. Schwabe uses specifically designed pharmacological models in order to reveal the mode of action. For this purpose, modern methods such as immunological assays and reporter gene assays using cell cultures and isolated tissues are applied. In addition, the compounds are tested in cell cultures or tissues.

The following pharmakokinetic investigations determine the fate of the new phytomedicine when administered to a living organism. This part of the development process tries to clarify the extent and rate a new substance is absorped, distributed, metabolized and excreted in and from the organism.

Schwabe’s plant extracts are thoroughly screened using relevant toxicological models to ensure optimal standards in the field of customer safety. Since extracts of the same plant yielded by different extraction methods are not comparable, these findings are usually not applicable to extracts of the same plant from other suppliers.